Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0476)
DME Name Brain form hexokinase (HK1), Homo sapiens DME Info
UniProt ID
HXK1_HUMAN
EC Number    EC: 2.7.1.1     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Alistipes indistinctus (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Alistipes indistinctus co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Anaerobutyricum hallii co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Anaerostipes caccae (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Anaerostipes caccae co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lactobacillus paracasei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Lactobacillus paracasei co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
                  Lactobacillus reuteri (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Lactobacillus reuteri co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6], [7]
                  Megasphaera elsdenii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              D-glucose Click to Show/Hide the Detail
                                 Drug ID DR2081   Drug Info
                                 Interaction Mechanism Human Brain form hexokinase (HK1) and Megasphaera elsdenii co-metabolize the drug D-glucose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [8], [9]
References
1 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.
2 Alistipes indistinctus sp. nov. and Odoribacter laneus sp. nov., common members of the human intestinal microbiota isolated from faeces. Int J Syst Evol Microbiol. 2010 Jun;60(Pt 6):1296-302.
3 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
4 Anaerostipes caccae gen. nov., sp. nov., a new saccharolytic, acetate-utilising, butyrate-producing bacterium from human faeces. Syst Appl Microbiol. 2002 Apr;25(1):46-51.
5 Administration of Lactobacillus paracasei ameliorates type 2 diabetes in mice. Food Funct. 2018 Jul 17;9(7):3630-3639.
6 1,3-Propanediol:NAD+ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol. 1992 Jun;58(6):2005-10.
7 Aciduric strains of Lactobacillus reuteri and Lactobacillus rhamnosus, isolated from human feces, have strong adhesion and aggregation properties. Probiotics Antimicrob Proteins. 2018 Mar;10(1):89-97.
8 Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
9 hole-Genome sequence of a Megasphaera elsdenii strain isolated from the gut of a healthy Indian adult subject. Genome Announc. 2017 Oct 19;5(42):e01033-17.

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