Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0485)
DME Name Glutamate-cysteine ligase catalytic (GCLC), Homo sapiens DME Info
UniProt ID
GSH1_HUMAN
EC Number    EC: 6.3.2.2     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bifidobacterium adolescentis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium angulatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bifidobacterium angulatum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Bifidobacterium dentium (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bifidobacterium dentium co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Aquificae
                  Aquifex pyrophilus (aquificales) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Aquifex pyrophilus co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Firmicutes
                  Bacillus anthracis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bacillus anthracis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bacillus pumilus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bacillus pumilus co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Bacillus subtilis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Bacillus subtilis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Lactobacillus brevis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactobacillus brevis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [2]
                  Lactobacillus casei (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactobacillus casei co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [5]
                  Lactobacillus fermentum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactobacillus fermentum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
                  Lactobacillus johnsonii (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactobacillus johnsonii co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4]
                  Lactobacillus plantarum (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactobacillus plantarum co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Lactococcus lactis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Lactococcus lactis co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Listeria monocytogenes (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Listeria monocytogenes co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
                  Streptococcus mutans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Streptococcus mutans co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [7]
      Bacteria: Proteobacteria
                  Escherichia coli (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Escherichia coli co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3], [6]
                  Shigella flexneri (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              L-glutamine Click to Show/Hide the Detail
                                 Drug ID DR0950   Drug Info
                                 Interaction Mechanism Human Glutamate-cysteine ligase catalytic (GCLC) and Shigella flexneri co-metabolize the drug L-glutamine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [6]
References
1 Kinetic measurement by LC/MS of gamma-glutamylcysteine ligase activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):32-8.
2 GABA production and structure of gadB/gadC genes in Lactobacillus and Bifidobacterium strains from human microbiota. Anaerobe. 2016 Dec;42:197-204.
3 Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J Mol Biol. 2007 Aug 31;371(5):1219-37.
4 Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Microb Cell Fact. 2018 Nov 19;17(1):180.
5 Mutagenesis of folylpolyglutamate synthetase indicates that dihydropteroate and tetrahydrofolate bind to the same site. Biochemistry. 2008 Feb 26;47(8):2388-96.
6 Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria: function, distribution and biomedical implications of the gadBC operon. Mol Microbiol. 2012 Nov;86(4):770-86.
7 Inactivation of glutamate racemase (MurI) eliminates virulence in Streptococcus mutans. Microbiol Res. 2016 May-Jun;186-187:1-8.

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