| General Information of Drug-Metabolizing Enzyme (DME ID: DME0489) |
| DME Name |
Liver-type arginase (ARG1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.3.1 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amidine hydrolase
EC: 3.5.3.1
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Firmicutes |
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| Staphylococcus petrasii (firmicutes) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| L-arginine |
Click to Show/Hide the Detail |
| Drug ID |
DR2103
Drug Info
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| Interaction Mechanism |
Human Liver-type arginase (ARG1) and Staphylococcus petrasii co-metabolize the drug L-arginine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13058-63.
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| 2 |
Staphylococcus jettensis sp. nov., a coagulase-negative staphylococcal species isolated from human clinical specimens. Int J Syst Evol Microbiol. 2013 Sep;63(Pt 9):3250-6.
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