| General Information of Drug-Metabolizing Enzyme (DME ID: DME0494) |
| DME Name |
Insulin-degrading enzyme (IDE), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.4.24.56 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallopeptidase
EC: 3.4.24.56
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Vibrio vulnificus (gamma-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Insulin |
Click to Show/Hide the Detail |
| Drug ID |
DR2102
Drug Info
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| Interaction Mechanism |
Human Insulin-degrading enzyme (IDE) and Vibrio vulnificus co-metabolize the drug Insulin, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
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| References |
| 1 |
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 2005 May 3;44(17):6513-25.
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| 2 |
Vibrio vulnificus secretes an insulin-degrading enzyme that promotes bacterial proliferation in vivo. J Biol Chem. 2015 Jul 24;290(30):18708-20.
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| 3 |
Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad. Gut Pathog. 2016 Jun 20;8:22.
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