| General Information of Drug-Metabolizing Enzyme (DME ID: DME0504) |
| DME Name |
NADP-dependent malic enzyme (ME1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.1.1.40 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.40
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Firmicutes |
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| Hungateiclostridium thermocellum (firmicutes) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Malate |
Click to Show/Hide the Detail |
| Drug ID |
DR2056
Drug Info
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| Interaction Mechanism |
Human NADP-dependent malic enzyme (ME1) and Hungateiclostridium thermocellum co-metabolize the drug Malate, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
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| References |
| 1 |
Structural characteristics of the nonallosteric human cytosolic malic enzyme. Biochim Biophys Acta. 2014 Oct;1844(10):1773-83.
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| 2 |
Thermostable, ammonium-activated malic enzyme of Clostridium thermocellum. Biochim Biophys Acta. 1981 Aug 13;660(2):251-5.
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| 3 |
The correlation between Clostridium-difficile infection and human gut concentrations of Bacteroidetes phylum and clostridial species. Eur J Clin Microbiol Infect Dis. 2014 Mar;33(3):377-83.
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