| General Information of Drug-Metabolizing Enzyme (DME ID: DME0536) |
| DME Name |
Phosphoglucomutase 3 (PGM3), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 5.4.2.3 (Click to Show/Hide the Complete EC Tree)
Isomerase
Mutase
Phosphomutase
EC: 5.4.2.3
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Firmicutes |
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| Lactobacillus acidophilus (firmicutes) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| NA-alpha-D-glucosamine |
Click to Show/Hide the Detail |
| Drug ID |
DR2111
Drug Info
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| Interaction Mechanism |
Human Phosphoglucomutase 3 (PGM3) and Lactobacillus acidophilus co-metabolize the drug NA-alpha-D-glucosamine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):369-76.
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| 2 |
Cloning, expression and characterization of a mucin-binding GAPDH from Lactobacillus acidophilus. Int J Biol Macromol. 2016 Oct;91:338-46.
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