Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0546)
DME Name Glucosidase II beta (PRKCSH), Homo sapiens DME Info
UniProt ID
GLU2B_HUMAN
EC Number    EC: 3.2.1.84     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.84
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium adolescentis (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              PNA-D-glucopyranoside Click to Show/Hide the Detail
                                 Drug ID DR2124   Drug Info
                                 Interaction Mechanism Human Glucosidase II beta (PRKCSH) and Bifidobacterium adolescentis co-metabolize the drug PNA-D-glucopyranoside, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Lentisphaerae
                  Victivallis vadensis (PVC bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              PNA-D-glucopyranoside Click to Show/Hide the Detail
                                 Drug ID DR2124   Drug Info
                                 Interaction Mechanism Human Glucosidase II beta (PRKCSH) and Victivallis vadensis co-metabolize the drug PNA-D-glucopyranoside, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
References
1 The heterodimeric structure of glucosidase II is required for its activity, solubility, and localization in vivo. Glycobiology. 2000 Aug;10(8):815-27.
2 Beta-galactosidase from Bifidobacterium adolescentis DSM20083 prefers beta(1,4)-galactosides over lactose. Appl Microbiol Biotechnol. 2004 Dec;66(3):276-84.
3 Identification and characterization of a novel beta-galactosidase from Victivallis vadensis ATCC BAA-548, an anaerobic fecal bacterium. J Microbiol. 2012 Dec;50(6):1034-40.

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