| General Information of Drug-Metabolizing Enzyme (DME ID: DME0579) |
| DME Name |
Glutamate carboxypeptidase II (FOLH1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.4.17.21 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallocarboxypeptidase
EC: 3.4.17.21
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Variovorax paradoxus (beta-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Methotrexate |
Click to Show/Hide the Detail |
| Drug ID |
DR1045
Drug Info
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| Interaction Mechanism |
Human Glutamate carboxypeptidase II (FOLH1) and Variovorax paradoxus co-metabolize the drug Methotrexate, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
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| References |
| 1 |
Understanding and managing methotrexate nephrotoxicity. Oncologist. 2006 Jun;11(6):694-703.
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| 2 |
The 46 kDa dimeric protein from Variovorax paradoxus shows faster methotrexate degrading activity in its nanoform compare to the native enzyme. Enzyme Microb Technol. 2016 Apr;85:38-43.
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| 3 |
Isolation and molecular detection of methylotrophic bacteria occurring in the human mouth. Environ Microbiol. 2005 Aug;7(8):1227-38.
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