| General Information of Drug-Metabolizing Enzyme (DME ID: DME0610) |
| DME Name |
Glutathione peroxidase 6 (GPX6), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.11.1.9 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.9
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Proteobacteria |
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| Ralstonia solanacearum (beta-proteobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| ANW-43980 |
Click to Show/Hide the Detail |
| Drug ID |
DR2036
Drug Info
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| Interaction Mechanism |
Human Glutathione peroxidase 6 (GPX6) and Ralstonia solanacearum co-metabolize the drug ANW-43980, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
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| References |
| 1 |
Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.
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| 2 |
Characterization of the mechanism of thioredoxin-dependent activation of gamma-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum. Biochem Biophys Res Commun. 2020 Mar 12;523(3):759-765.
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| 3 |
Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study. BJOG. 2019 Feb;126(3):349-358.
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