| General Information of Drug-Metabolizing Enzyme (DME ID: DME1061) |
| DME Name |
Tyrosine decarboxylase (tdc), Enterococcus faecalis
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DME Info
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| UniProt ID |
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| EC Number |
EC: 4.1.1.25 (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.25
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| Lineage |
Species: Enterococcus faecalis (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecalis
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Actinobacteria |
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| Eggerthella lenta |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Levodopa |
Click to Show/Hide the Detail |
| Drug ID |
DR0939
Drug Info
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| Interaction Mechanism |
The DME Tyrosine decarboxylase (tdc) form Enterococcus faecalis metabolizes the drug Levodopa, and the microbe Eggerthella lenta further metabolizes its metabolite (Dopamine hydrochloride), which can collectively affect efficacy, safety or bioavailability of this drug. |
[1] |
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| References |
| 1 |
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. Science. 2019 Jun 14;364(6445). pii: eaau6323.
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