Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0165)
DME Name Transglutaminase E (TGM3), Homo sapiens DME Info
UniProt ID
TGM3_HUMAN
EC Number    EC: 2.3.2.13     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Aminoacyltransferase
EC: 2.3.2.13
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Mixture Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Particulate matter Click to Show/Hide the Detail Induction
                                 XEOTIC ID XEO00919   XEOTIC Info Gene Form mRNA
                                 Classification Natural Mixture
                                 DME Modulation Particulate matter up-regulates the expression of DME TGM3 [1]
                              Tobacco smoke pollution Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00821   XEOTIC Info Gene Form Protein
                                 Classification Natural Mixture
                                 DME Modulation Tobacco smoke pollution inhibits the drug-metabolizing activity of DME TGM3 [2]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Calcitriol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00184   XEOTIC Info Gene Form mRNA
                                 Classification Drug Approved by US FDA
                                 DME Modulation Calcitriol inhibits the expression of DME TGM3 [3]
                  Preclinical/Patented Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              (+)-JQ1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00723   XEOTIC Info Gene Form mRNA
                                 Classification Drug in Preclinical Study
                                 DME Modulation (+)-JQ1 inhibits the expression of DME TGM3 [4]
References
1 Nrf2/ARE pathway involved in oxidative stress induced by paraquat in human neural progenitor cells. Oxid Med Cell Longev. 2016;2016:8923860.
2 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
3 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
4 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.

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