Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0440)
DME Name VKORC1-like protein 1 (VKORC1L1), Homo sapiens DME Info
UniProt ID
VKORL_HUMAN
EC Number    EC: 1.17.4.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
Disulfide acceptor oxidoreductase
EC: 1.17.4.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bromadiolone Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01616   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Bromadiolone inhibits the drug-metabolizing activity of DME VKORC1L1 [1]
                              Coumatetralyl Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01617   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Coumatetralyl inhibits the drug-metabolizing activity of DME VKORC1L1 [1]
                              Formaldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01305   XEOTIC Info Gene Form mRNA
                                 Classification Acute Toxic Substance
                                 DME Modulation Formaldehyde inhibits the expression of DME VKORC1L1 [2]
                  Carcinogen Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Ethyl methanesulfonate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00772   XEOTIC Info Gene Form mRNA
                                 Classification Carcinogen
                                 DME Modulation Ethyl methanesulfonate inhibits the expression of DME VKORC1L1 [2]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Phenprocoumon Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00206   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Phenprocoumon inhibits the drug-metabolizing activity of DME VKORC1L1 [3]
                              Acenocoumarol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00513   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Acenocoumarol inhibits the drug-metabolizing activity of DME VKORC1L1 [1]
                              Fluindione Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00471   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Fluindione inhibits the drug-metabolizing activity of DME VKORC1L1 [1]
                  Drug in Phase 2 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bisphenol A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01226   XEOTIC Info Gene Form mRNA
                                 Classification Highest Clinical Status: Phase 2
                                 DME Modulation Bisphenol A inhibits the expression of DME VKORC1L1 [4]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              4-hydroxycoumarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00866   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation 4-hydroxycoumarin inhibits the drug-metabolizing activity of DME VKORC1L1 [1]
References
1 VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites. Blood Adv. 2018 Mar 27;2(6):691-702.
2 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
3 NRH:quinone oxidoreductase2 (NQO2). Chem Biol Interact. 2000 Dec 1;129(1-2):99-112.
4 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.

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