Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1033)
DME Name Beta-lactamase (blaB), Edwardsiella tarda DME Info
UniProt ID
A4LA84_EDWTA
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Edwardsiella tarda     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Hafniaceae
Genus: Edwardsiella
Species: Edwardsiella tarda
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Anti-lipopolysaccharide factor PtALF5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04758   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Anti-lipopolysaccharide factor PtALF5 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Edwardsiella tarda (MIC = 7.78-15.54 microM) [1], [2]
                              Anti-lipopolysaccharide factor PtALF7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04760   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Anti-lipopolysaccharide factor PtALF7 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Edwardsiella tarda (MIC = 2.04-4.07 microM) [1], [3]
      Health or Environmental Toxicant(s)
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Coumarin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00879   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Coumarin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Edwardsiella tarda [4]
References
1 Multiple isoforms of immune-related genes from hemocytes and eyestalk cDNA libraries of swimming crab Portunus trituberculatus. Fish Shellfish Immunol. 2011 Jul;31(1):29-42.
2 Molecular cloning, expression pattern and antimicrobial activity of a new isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus. Fish Shellfish Immunol. 2012 Jul;33(1):85-91.
3 Molecular cloning, genomic structure and antimicrobial activity of PtALF7, a unique isoform of anti-lipopolysaccharide factor from the swimming crab Portunus trituberculatus. Fish Shellfish Immunol. 2013 Feb;34(2):652-9.
4 Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens. Appl Microbiol Biotechnol. 2015 Apr;99(7):3303-16.

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