Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1047)
DME Name Beta-glucosidase (bglA), Trichophyton rubrum DME Info
UniProt ID
F2SBM1_TRIRC
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Trichophyton rubrum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Species: Trichophyton rubrum
Subspecies: Trichophyton rubrum NCPF 0118
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Antifungal peptide Cm-p1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antifungal peptide Cm-p1 inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum (MIC = 3 microM) [1]
                              Cm-p1 derivative Cm-p3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02892   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cm-p1 derivative Cm-p3 inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum (MIC = 128 ug/ml) [2]
                              Cm-p1 derivative Cm-p4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02893   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cm-p1 derivative Cm-p4 inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum (MIC = 32 ug/ml) [2]
                              Cm-p1 derivative Cm-p5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02894   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cm-p1 derivative Cm-p5 inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum (MIC = 10 ug/ml) [2]
                              Diapause-specific peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03176   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Diapause-specific peptide inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum [3]
                              Lectin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03849   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lectin inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum (MIC = 65 ug/ml) [4]
                              V. radiata defensin VrD1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05261   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation V. radiata defensin VrD1 inhibits the drug-metabolizing activity of Beta-glucosidase (bglA) from Trichophyton rubrum [5]
References
1 Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus. Biochimie. 2012 Apr;94(4):968-74.
2 Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J. 2015 Aug;29(8):3315-25.
3 The structure of a novel insect peptide explains its Ca2+ channel blocking and antifungal activities. Biochemistry. 2007 Dec 4;46(48):13733-41.
4 Ganoderma lucidum: a source for novel bioactive lectin. Protein Pept Lett. 2011 Nov;18(11):1150-7.
5 Cloning and functional expression of a mungbean defensin VrD1 in Pichia pastoris. J Agric Food Chem. 2004 Apr 21;52(8):2256-61.

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