Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1123)
DME Name Glutamate racemase (MurI), Lactobacillus fermentum DME Info
UniProt ID
MURI_LACFE
EC Number    EC: 5.1.1.3     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Amino acid racemase/epimerase
EC: 5.1.1.3
Lineage    Species: Lactobacillus fermentum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus fermentum
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Acidocin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02126   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin A inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Lactobacillus fermentum [1]
                              Acidocin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02127   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin B inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Lactobacillus fermentum [2]
                              Cryptdin related peptide CRS4C-1a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02958   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cryptdin related peptide CRS4C-1a inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Lactobacillus fermentum [3]
                              Thuricin CDalpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05136   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thuricin CDalpha inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Lactobacillus fermentum [4], [5]
                              Thuricin CDdbeta Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05137   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thuricin CDdbeta inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Lactobacillus fermentum [4], [5]
References
1 Isolation and characterization of acidocin A and cloning of the bacteriocin gene from Lactobacillus acidophilus. Appl Environ Microbiol. 1995 Mar;61(3):1061-7.
2 Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus. Microbiology. 1995 Jul;141 ( Pt 7):1629-35.
3 Increased diversity of intestinal antimicrobial peptides by covalent dimer formation. Nat Immunol. 2004 Aug;5(8):836-43.
4 Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9352-7.
5 The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to alpha-carbon cross-links. J Am Chem Soc. 2011 May 25;133(20):7680-3.

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