Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1126)
DME Name Glutamate racemase (MurI), Bacillus anthracis DME Info
UniProt ID
Q81UL8_BACAN
EC Number    EC: 5.1.1.3     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Amino acid racemase/epimerase
EC: 5.1.1.3
Lineage    Species: Bacillus anthracis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus anthracis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Amythiamicin A/B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02206   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Amythiamicin A/B inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 0.1 ug/ml) [1]
                              Antimicrobial protein AN5-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02298   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial protein AN5-1 inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 128 ug/ml) [2]
                              Geobacillin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03478   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Geobacillin I inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis [3]
                              Omwaprin-a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04394   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Omwaprin-a inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis [4], [5]
                              Plantazolicin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04624   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantazolicin inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 2-4 ug/ml) [6]
                              Rational design peptide D22 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03056   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rational design peptide D22 inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 64 ug/ml) [7]
                              Rational design peptide D28 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03057   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rational design peptide D28 inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 16 ug/ml) [7]
                              Rational design peptide D51 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03065   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Rational design peptide D51 inhibits the drug-metabolizing activity of Glutamate racemase (MurI) from Bacillus anthracis (MIC = 16 ug/ml) [7]
References
1 Novel antibiotics, amythiamicinsI. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity. J Antibiot (Tokyo). 1994 Jun;47(6):668-74.
2 Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5. J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-9.
3 Lantibiotics from Geobacillus thermodenitrificans. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5241-6.
4 Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins. Biochem J. 2007 Feb 15;402(1):93-104.
5 Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography. Protein Sci. 2010 Oct;19(10):1840-9.
6 Plantazolicin, a novel microcin B17/streptolysin S-like natural product from Bacillus amyloliquefaciens FZB42. J Bacteriol. 2011 Jan;193(1):215-24.
7 A linguistic model for the rational design of antimicrobial peptides. Nature. 2006 Oct 19;443(7113):867-9.

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