Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1143)
DME Name Hyaluronidase (hyl), Bacillus megaterium DME Info
UniProt ID
W5RSC1_9BACI
EC Number    EC: 4.2.2.1     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-oxygen lyase
Polysaccharide-lyase
EC: 4.2.2.1
Lineage    Species: Bacillus megaterium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus megaterium
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              V. philippinarum beta defensin VpBD Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05260   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation V. philippinarum beta defensin VpBD inhibits the drug-metabolizing activity of Hyaluronidase (hyl) from Bacillus megaterium (MIC = 13.13-26.26 microM) [1]
                              Venom antimicrobial peptide-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05230   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Venom antimicrobial peptide-6 inhibits the drug-metabolizing activity of Hyaluronidase (hyl) from Bacillus megaterium (MIC = 2 microM) [2]
                              Venom antimicrobial peptide-9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05231   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Venom antimicrobial peptide-9 inhibits the drug-metabolizing activity of Hyaluronidase (hyl) from Bacillus megaterium (MIC = 0.60 microM) [2]
References
1 Molecular characterization of a novel big defensin from clam Venerupis philippinarum. PLoS One. 2010 Oct 20;5(10):e13480.
2 Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. FASEB J. 2009 Apr;23(4):1230-45.

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