Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1149)
DME Name CDP-alcohol phosphatidyltransferase (pgsA), Streptococcus mitis DME Info
UniProt ID
A0A081Q830_STRMT
EC Number    EC: 2.7.8.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.8.5
Lineage    Species: Streptococcus mitis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus mitis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Mutacin-1140 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04155   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin-1140 inhibits the drug-metabolizing activity of CDP-alcohol phosphatidyltransferase (pgsA) from Streptococcus mitis [1]
                              Nisin U Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04320   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin U inhibits the drug-metabolizing activity of CDP-alcohol phosphatidyltransferase (pgsA) from Streptococcus mitis [2]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Limonene Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01559   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Limonene inhibits the drug-metabolizing activity of CDP-alcohol phosphatidyltransferase (pgsA) from Streptococcus mitis [3]
References
1 Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics. Eur J Biochem. 2000 Dec;267(23):6810-6.
2 Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol. 2006 Feb;72(2):1148-56.
3 Limonene inhibits streptococcal biofilm formation by targeting surface-associated virulence factors. J Med Microbiol. 2015 Aug;64(8):879-890.

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