General Information of Drug-Metabolizing Enzyme (DME ID: DME1153)
DME Name Histidine decarboxylase (hdcA), Lactobacillus reuteri DME Info
UniProt ID
A0A0K6GJ74_LACRE
EC Number    EC: 4.1.1.22     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.22
Lineage    Species: Lactobacillus reuteri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus reuteri
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Garvicin ML Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03473   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Garvicin ML inhibits the drug-metabolizing activity of Histidine decarboxylase (hdcA) from Lactobacillus reuteri [1]
                              Nisin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04319   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin F inhibits the drug-metabolizing activity of Histidine decarboxylase (hdcA) from Lactobacillus reuteri [2]
References
1 Characterization of garvicin ML, a novel circular bacteriocin produced by Lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Appl Environ Microbiol. 2011 Jan;77(1):369-73.
2 Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsplactis isolate from freshwater catfish (Clarias gariepinus). Appl Environ Microbiol. 2008 Jan;74(2):547-9.

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