Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1154)
DME Name ATP-dependent 6-phosphofructokinase (pfkA), Lactobacillus delbrueckii DME Info
UniProt ID
PFKA_LACDE
EC Number    EC: 2.7.1.11     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.11
Lineage    Species: Lactobacillus delbrueckii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus delbrueckii
Subspecies: Lactobacillus delbrueckii subsp. bulgaricus
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Acidocin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02126   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin A inhibits the drug-metabolizing activity of ATP-dependent 6-phosphofructokinase (pfkA) from Lactobacillus delbrueckii [1]
                              Acidocin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02127   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin B inhibits the drug-metabolizing activity of ATP-dependent 6-phosphofructokinase (pfkA) from Lactobacillus delbrueckii [2]
                              Bacteriocin hiracin-JM79 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02377   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin hiracin-JM79 inhibits the drug-metabolizing activity of ATP-dependent 6-phosphofructokinase (pfkA) from Lactobacillus delbrueckii [3]
                              Protease-activated antimicrobial peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04730   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Protease-activated antimicrobial peptide inhibits the drug-metabolizing activity of ATP-dependent 6-phosphofructokinase (pfkA) from Lactobacillus delbrueckii (MIC = 0.0005 microM) [4]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of ATP-dependent 6-phosphofructokinase (pfkA) from Lactobacillus delbrueckii [5]
References
1 Isolation and characterization of acidocin A and cloning of the bacteriocin gene from Lactobacillus acidophilus. Appl Environ Microbiol. 1995 Mar;61(3):1061-7.
2 Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus. Microbiology. 1995 Jul;141 ( Pt 7):1629-35.
3 Amino acid and nucleotide sequence, adjacent genes, and heterologous expression of hiracin JM79, a sec-dependent bacteriocin produced by Enterococcus hirae DCH5, isolated from Mallard ducks (Anas platyrhynchos). FEMS Microbiol Lett. 2007 May;270(2):227-36.
4 An antimicrobial peptide is produced by extracellular processing of a protein from Propionibacterium jensenii. J Bacteriol. 2002 Jul;184(13):3649-56.
5 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.

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