Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1170)
DME Name Dextransucrase 4 (dsrF4), Leuconostoc mesenteroides DME Info
UniProt ID
GTF4_LEUME
EC Number    EC: 2.4.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Hexosyltransferase
EC: 2.4.1.5
Lineage    Species: Leuconostoc mesenteroides     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Leuconostocaceae
Genus: Leuconostoc
Species: Leuconostoc mesenteroides
Subspecies: Leuconostoc mesenteroides 0326
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      18 Xenobiotics
                              Bacteriocin HJ50 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02476   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin HJ50 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [1], [2]
                              Bacteriocin lacticin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03771   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lacticin Q inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [3]
                              Bacteriocin leucocin N Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03854   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin N inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides (MIC = 2.60 microM) [4]
                              Bacteriocin leucocin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03855   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin Q inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides (MIC = 4.10 microM) [4]
                              Bacteriocin plantarican ASM1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02382   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin plantarican ASM1 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [5]
                              Carnocyclin CclA Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02721   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Carnocyclin CclA inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [6], [7]
                              Enterocin 96 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin 96 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [8]
                              Enterocin RJ-11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03258   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin RJ-11 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [9]
                              Frenatin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03406   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Frenatin-3 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides (MIC = 25 ug/ml) [10]
                              Lantibiotic paenibacillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03806   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic paenibacillin inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [11], [12]
                              Leucocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03857   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leucocyclicin Q inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides (MIC = 0.3 microM) [13]
                              Mundticin ATO6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04150   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mundticin ATO6 inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [14]
                              Penocin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04521   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penocin A inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [15], [16]
                              Plantaricin W alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04622   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin W alpha inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [17]
                              Plantaricin W beta Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04623   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin W beta inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [17]
                              Subpeptin JM4-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05004   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-A inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [18]
                              Subpeptin JM4-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05005   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-B inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [18]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of Dextransucrase 4 (dsrF4) from Leuconostoc mesenteroides [19]
References
1 Bovicin HJ50, a novel lantibiotic produced by Streptococcus bovis HJ50. Microbiology. 2004 Jan;150(Pt 1):103-108.
2 Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50. Microbiology. 2009 Feb;155(Pt 2):584-593.
3 Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria. Appl Environ Microbiol. 2007 May;73(9):2871-7.
4 Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15. J Appl Microbiol. 2010 Jul;109(1):282-91.
5 Isolation and characterization of plantaricin ASM1: a new bacteriocin produced by Lactobacillus plantarum A-1. Int J Food Microbiol. 2010 Jan 31;137(1):94-9.
6 Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol. 2008 Aug;74(15):4756-63.
7 The three-dimensional structure of carnocyclin A reveals that many circular bacteriocins share a common structural motif. J Biol Chem. 2009 Oct 16;284(42):28674-81.
8 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4.
9 Purification and characterization of a novel bacteriocin produced by Enterococcus faecalis strain RJ-11. Appl Environ Microbiol. 2003 Oct;69(10):5746-53.
10 The structures of the frenatin peptides from the skin secretion of the giant tree frog Litoria infrafrenata. J Pept Sci. 1996 Mar-Apr;2(2):117-24.
11 Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol. 2007 Jan;73(1):168-78.
12 N-terminal acetylation in paenibacillin, a novel lantibiotic. FEBS Lett. 2008 Aug 6;582(18):2787-92.
13 Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 2011 Nov;77(22):8164-70.
14 A novel bacteriocin with a YGNGV motif from vegetable-associated Enterococcus mundtii: full characterization and interaction with target organisms. Biochim Biophys Acta. 1998 Aug 14;1373(1):47-58.
15 Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15611-6.
16 Data mining and characterization of a novel pediocin-like bacteriocin system from the genome of Pediococcus pentosaceus ATCC 25745. Microbiology. 2006 Jun;152(Pt 6):1649-59.
17 Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics. Microbiology. 2001 Mar;147(Pt 3):643-651.
18 Purification and characterization of two novel antimicrobial peptides Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4. Curr Microbiol. 2005 Nov;51(5):292-6.
19 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.

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