Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1199)
DME Name L,D-carboxypeptidase A (ldcA), Neisseria gonorrhoeae DME Info
UniProt ID
A0A5K1KMI8_NEIGO
EC Number    EC: 3.4.17.13     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallocarboxypeptidase
EC: 3.4.17.13
Lineage    Species: Neisseria gonorrhoeae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Neisseriaceae
Genus: Neisseria
Species: Neisseria gonorrhoeae
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Canine beta-defensin cBD-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02749   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Canine beta-defensin cBD-1 inhibits the drug-metabolizing activity of L,D-carboxypeptidase A (ldcA) from Neisseria gonorrhoeae (MIC = 50 mug/ml) [1]
                              Cathelicidin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02732   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-1 inhibits the drug-metabolizing activity of L,D-carboxypeptidase A (ldcA) from Neisseria gonorrhoeae (MIC = 0.06 microM) [2]
                              Halocyntin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03522   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Halocyntin inhibits the drug-metabolizing activity of L,D-carboxypeptidase A (ldcA) from Neisseria gonorrhoeae [3]
                              Mutacin II mutacin H-29B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04156   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin II mutacin H-29B inhibits the drug-metabolizing activity of L,D-carboxypeptidase A (ldcA) from Neisseria gonorrhoeae [4]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of L,D-carboxypeptidase A (ldcA) from Neisseria gonorrhoeae (MIC > 20 microM) [5]
References
1 Molecular cloning and characterization of three beta-defensins from canine testes. Infect Immun. 2005 May;73(5):2611-20.
2 Canine cathelicidin (K9CATH): gene cloning, expression, and biochemical activity of a novel pro-myeloid antimicrobial peptide. Dev Comp Immunol. 2007;31(12):1278-96.
3 Halocyntin and papillosin, two new antimicrobial peptides isolated from hemocytes of the solitary tunicate, Halocynthia papillosa. J Pept Sci. 2009 Jan;15(1):48-55.
4 Mutacin H-29B is identical to mutacin II (J-T8). BMC Microbiol. 2006 Apr 20;6:36.
5 Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-9.

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