Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1288)
DME Name	Unclear metabolic mechanism (DME-unclear), Shewanella oneidensis	DME Info
Lineage	Species: Shewanella oneidensis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Alteromonadales Family: Shewanellaceae Genus: Shewanella Species: Shewanella oneidensis Subspecies: Shewanella oneidensis MR-1
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Venom antimicrobial peptide-6		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05230 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Venom antimicrobial peptide-6 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Shewanella oneidensis (MIC = 6.20 microM)				[1]
Venom antimicrobial peptide-9		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO05231 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Venom antimicrobial peptide-9 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Shewanella oneidensis (MIC = 1.50 microM)				[1]

References
1	Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides. FASEB J. 2009 Apr;23(4):1230-45.

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