Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1331)
DME Name Nitroreductase (NTR), Clostridium sporogenes DME Info
UniProt ID
A0A2X3BKF5_CLOSG
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Clostridium sporogenes     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Clostridium
Species: Clostridium sporogenes
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Acidocin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02126   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin A inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Clostridium sporogenes [1]
                              Acidocin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02127   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Acidocin B inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Clostridium sporogenes [2]
                              Enterocin P Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03257   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin P inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Clostridium sporogenes (MIC = 0.004 ug/ml) [3], [4]
                              Lantibiotic paenibacillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03806   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic paenibacillin inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Clostridium sporogenes [5], [6]
                              Mutacin II mutacin H-29B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04156   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin II mutacin H-29B inhibits the drug-metabolizing activity of Nitroreductase (NTR) from Clostridium sporogenes [7]
References
1 Isolation and characterization of acidocin A and cloning of the bacteriocin gene from Lactobacillus acidophilus. Appl Environ Microbiol. 1995 Mar;61(3):1061-7.
2 Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus. Microbiology. 1995 Jul;141 ( Pt 7):1629-35.
3 Biochemical and genetic characterization of enterocin P, a novel sec-dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum. Appl Environ Microbiol. 1997 Nov;63(11):4321-30.
4 Single nucleotide polymorphism analysis of the enterocin P structural gene of Enterococcus faecium strains isolated from nonfermented animal foods. Mol Nutr Food Res. 2006 Dec;50(12):1229-38.
5 Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol. 2007 Jan;73(1):168-78.
6 N-terminal acetylation in paenibacillin, a novel lantibiotic. FEBS Lett. 2008 Aug 6;582(18):2787-92.
7 Mutacin H-29B is identical to mutacin II (J-T8). BMC Microbiol. 2006 Apr 20;6:36.

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