Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1332)
DME Name Beta-lactamase (blaB), Burkholderia cepacia DME Info
UniProt ID
A0A2S8IKB0_BURCE
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia cepacia     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia cepacia
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Beta-defensin BD-8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02443   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Beta-defensin BD-8 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [1]
                              CTX-1 peptide NCP-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04241   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3a inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [2]
                              CTX-1 peptide NCP-3b Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04242   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3b inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [2]
                              Dermatoxin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03164   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dermatoxin inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [3]
                              Hydramacin Hm-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03609   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hydramacin Hm-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [4], [5]
                              Murine beta-defensin related peptide Defr1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03127   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Murine beta-defensin related peptide Defr1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [6]
                              NCP-0 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04240   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation NCP-0 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [2]
                              Piscidin Pis-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04612   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-1 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia (MIC > 20 microM) [7]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia (MIC > 20 microM) [8]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Copper sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00117   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Copper sulfate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [9]
                              Silver nitrate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00511   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Silver nitrate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [9]
                              Zinc sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00460   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Zinc sulfate inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [9]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Carboxymethyl chitosan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02714   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Carboxymethyl chitosan inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Burkholderia cepacia [9]
References
1 Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci. 2001 Dec;10(12):2470-9.
2 Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018 Jan 24;13(1):e0190778.
3 Isolation of dermatoxin from frog skin, an antibacterial peptide encoded by a novel member of the dermaseptin genes family. Eur J Biochem. 2000 Jul;267(14):4583-92.
4 Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol. 2009 Apr;33(4):559-69.
5 Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem. 2009 Jan 16;284(3):1896-905.
6 Identification and characterization of a novel murine beta-defensin-related gene. Mamm Genome. 2002 Aug;13(8):445-51.
7 Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9.
8 Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-9.
9 Inhibition of bacterial biofilms by carboxymethyl chitosan combined with silver, zinc and copper salts. Int J Biol Macromol. 2017 Dec;105(Pt 1):385-392.

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