Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1339)
DME Name Glutamate decarboxylase (gadB), Lactobacillus plantarum DME Info
UniProt ID
A0A1E3KVW8_LACPN
EC Number    EC: 4.1.1.15     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.15
Lineage    Species: Lactobacillus plantarum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus plantarum
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      26 Xenobiotics
                              Antimicrobial protein AN5-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02298   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial protein AN5-1 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 32 ug/ml) [1]
                              Bacteriocin curvaticin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02375   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin curvaticin inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [2]
                              Bacteriocin leucocin N Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03854   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin N inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 2.60 microM) [3]
                              Bacteriocin leucocin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03855   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin Q inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 4.10 microM) [3]
                              Bacteriocin LSEI_2163 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03967   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin LSEI_2163 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [4]
                              Bacteriocin plantarican ASM1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02382   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin plantarican ASM1 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [5]
                              Bacteriocin PlnA-17 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04658   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin PlnA-17 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [6]
                              Bacteriocin PlnA-22 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04659   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin PlnA-22 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [6]
                              Carnobacteriocin CbnB2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02718   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Carnobacteriocin CbnB2 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [7]
                              Enterocin 96 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03250   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin 96 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [8]
                              Enterocin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03252   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin B inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.0869 microM) [9], [10]
                              Enterocin X alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin X alpha inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.102 microM) [11]
                              Enterocin X beta Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03260   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin X beta inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.813 microM) [11]
                              Garvieacin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03474   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Garvieacin Q inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [12]
                              Glycocin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03493   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Glycocin F inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [13], [14]
                              Mundticin KS Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04151   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mundticin KS inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [15]
                              Nisin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04319   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin F inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [16]
                              Pediocin PA-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04501   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pediocin PA-1 inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [17], [18]
                              Plantaricin E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04616   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin E inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.007 microM) [19], [20]
                              Plantaricin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04617   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin F inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.007 microM) [20], [21]
                              Plantaricin J Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04618   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin J inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.0001 microM) [21], [22]
                              Plantaricin K Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04619   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin K inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.0001 microM) [21], [22]
                              Protease-activated antimicrobial peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04730   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Protease-activated antimicrobial peptide inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum (MIC = 0.116 microM) [23]
                              Subpeptin JM4-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05004   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-A inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [24]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [25]
                              Weissellin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05283   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Weissellin-A inhibits the drug-metabolizing activity of Glutamate decarboxylase (gadB) from Lactobacillus plantarum [26]
References
1 Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5. J Ind Microbiol Biotechnol. 2013 Jun;40(6):571-9.
2 Purification and characterization of curvaticin L442, a bacteriocin produced by Lactobacillus curvatus L442. Antonie Van Leeuwenhoek. 2006 Jan;89(1):19-26.
3 Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15. J Appl Microbiol. 2010 Jul;109(1):282-91.
4 Characterization of putative class II bacteriocins identified from a non-bacteriocin-producing strain Lactobacillus casei ATCC 334. Appl Microbiol Biotechnol. 2013 Jan;97(1):237-46.
5 Isolation and characterization of plantaricin ASM1: a new bacteriocin produced by Lactobacillus plantarum A-1. Int J Food Microbiol. 2010 Jan 31;137(1):94-9.
6 Structure and mode of action of the membrane-permeabilizing antimicrobial peptide pheromone plantaricin A. J Biol Chem. 2005 Jun 17;280(24):22945-50.
7 Chemical and genetic characterization of bacteriocins produced by Carnobacterium piscicola LV17B. J Biol Chem. 1994 Apr 22;269(16):12204-11.
8 Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis. Science. 2003 Mar 28;299(5615):2071-4.
9 Atypical genetic locus associated with constitutive production of enterocin B by Enterococcus faecium BFE 900. Appl Environ Microbiol. 1999 May;65(5):2170-8.
10 Enterocin B, a new bacteriocin from Enterococcus faecium T136 which can act synergistically with enterocin A. Microbiology. 1997 Jul;143 ( Pt 7):2287-94.
11 Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides. Appl Environ Microbiol. 2010 Jul;76(13):4542-5.
12 Garvieacin Q, a novel class II bacteriocin from Lactococcus garvieae BCC 43578. Appl Environ Microbiol. 2012 Mar;78(5):1619-23.
13 Structural, dynamic, and chemical characterization of a novel S-glycosylated bacteriocin. Biochemistry. 2011 Apr 12;50(14):2748-55.
14 Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins. FEBS Lett. 2011 Feb 18;585(4):645-50.
15 Biochemical and genetic characterization of mundticin KS, an antilisterial peptide produced by Enterococcus mundtii NFRI 7393. Appl Environ Microbiol. 2002 Aug;68(8):3830-40.
16 Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsplactis isolate from freshwater catfish (Clarias gariepinus). Appl Environ Microbiol. 2008 Jan;74(2):547-9.
17 Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0. Appl Environ Microbiol. 1992 Aug;58(8):2360-7.
18 Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0. Arch Biochem Biophys. 1992 May 15;295(1):5-12.
19 The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system. Appl Environ Microbiol. 1994 Jan;60(1):160-6.
20 Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin plantaricin EF. Biochim Biophys Acta. 2008 Nov;1784(11):1711-9.
21 Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A. Appl Environ Microbiol. 1998 Jun;64(6):2269-72.
22 Three-dimensional structure of the two-peptide bacteriocin plantaricin JK. Peptides. 2009 Sep;30(9):1613-21.
23 An antimicrobial peptide is produced by extracellular processing of a protein from Propionibacterium jensenii. J Bacteriol. 2002 Jul;184(13):3649-56.
24 Purification and characterization of two novel antimicrobial peptides Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4. Curr Microbiol. 2005 Nov;51(5):292-6.
25 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.
26 Purification, amino acid sequence and characterization of the class IIa bacteriocin weissellin A, produced by Weissella paramesenteroides DX. Bioresour Technol. 2011 Jun;102(12):6730-4.

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