Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1350)
DME Name Beta-glucuronidase (uidA), Streptococcus agalactiae DME Info
UniProt ID
A0A0E1EGE5_STRAG
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Streptococcus agalactiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus agalactiae
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      12 Xenobiotics
                              Amphiphatic peptide VmCT1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02202   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Amphiphatic peptide VmCT1 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 20 microM) [1]
                              Amphiphatic peptide VmCT2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02203   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Amphiphatic peptide VmCT2 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 20 microM) [1]
                              Aureocin A53 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02347   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Aureocin A53 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae [2]
                              CTX-1 peptide NCP-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04241   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3a inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae [3]
                              CTX-1 peptide NCP-3b Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04242   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CTX-1 peptide NCP-3b inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae [3]
                              Lantibiotic paenibacillin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03806   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic paenibacillin inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae [4], [5]
                              Nisin U Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04320   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin U inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae [6]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 1.25-2.5 microM) [7]
                              Temporin-Ra Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05101   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-Ra inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 24.7 ug/ml) [8]
                              Temporin-Rb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05102   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-Rb inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 30.5 ug/ml) [8]
                              Tilapia piscidin 3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05148   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tilapia piscidin 3 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 9.78 ug/ml) [9], [10]
                              Tilapia piscidin 4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05149   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tilapia piscidin 4 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Streptococcus agalactiae (MIC = 2.1 ug/ml) [11]
References
1 Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. Peptides. 2012 Apr;34(2):290-5.
2 Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus. J Mol Biol. 2002 Jun 7;319(3):745-56.
3 Novel Naja atra cardiotoxin 1 (CTX-1) derived antimicrobial peptides with broad spectrum activity. PLoS One. 2018 Jan 24;13(1):e0190778.
4 Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol. 2007 Jan;73(1):168-78.
5 N-terminal acetylation in paenibacillin, a novel lantibiotic. FEBS Lett. 2008 Aug 6;582(18):2787-92.
6 Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol. 2006 Feb;72(2):1148-56.
7 Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-9.
8 Identification and characterization of two novel antimicrobial peptides, temporin-Ra and temporin-Rb, from skin secretions of the marsh frog (Rana ridibunda). J Pept Sci. 2012 Jan;18(1):10-6.
9 Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. PLoS One. 2012;7(11):e50263.
10 Use of tilapia piscidin 3 (TP3) to protect against MRSA infection in mice with skin injuries. Oncotarget. 2015 May 30;6(15):12955-69.
11 MSP-4, an antimicrobial peptide, induces apoptosis via activation of extrinsic Fas/FasL- and intrinsic mitochondria-mediated pathways in one osteosarcoma cell line. Mar Drugs. 2018 Jan 2;16(1).

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