Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1448)
DME Name Unclear metabolic mechanism (DME-unclear), Porphyromonas gingivalis DME Info
Lineage    Species: Porphyromonas gingivalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Porphyromonadaceae
Genus: Porphyromonas
Species: Porphyromonas gingivalis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Human MUC7 20-Mer Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04146   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Human MUC7 20-Mer inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Porphyromonas gingivalis [1]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Metronidazole Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04108   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Metronidazole inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Porphyromonas gingivalis [2]
                              Lactoferrin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03778   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Lactoferrin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Porphyromonas gingivalis [3]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Oxantel Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04419   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Oxantel inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Porphyromonas gingivalis [2]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              9-hydroxy-2-propyl-4H-pyrido[1,2-a]pyrimidin-4-one Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02101   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 9-hydroxy-2-propyl-4H-pyrido[1,2-a]pyrimidin-4-one inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Porphyromonas gingivalis [4]
References
1 MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action. Antimicrob Agents Chemother. 2003 Feb;47(2):643-52.
2 Inhibition of Porphyromonas gingivalis biofilm by oxantel. Antimicrob Agents Chemother. 2010 Mar;54(3):1311-4.
3 Lactoferrin inhibits Porphyromonas gingivalis proteinases and has sustained biofilm inhibitory activity. Antimicrob Agents Chemother. 2012 Mar;56(3):1548-56.
4 Effects of N-acyl homoserine lactone analogues on Porphyromonas gingivalis biofilm formation. J Periodontal Res. 2010 Apr;45(2):255-61.

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