Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1630)
DME Name VanA ligase (vanA), Enterococcus gallinarum DME Info
UniProt ID
A0A376GZ73_ENTGA
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus gallinarum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus gallinarum
Subspecies: Enterococcus gallinarum BM4231
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01961   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanA ligase (vanA) from Enterococcus gallinarum [1]
                              3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01966   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanA ligase (vanA) from Enterococcus gallinarum [1]
References
1 Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation. Antimicrob Agents Chemother. 2009 Oct;53(10):4357-67.

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