Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1714)
DME Name Alpha-galactosidase (melA), Lactobacillus acidophilus DME Info
UniProt ID
MELA_LACAC
EC Number    EC: 3.2.1.22     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.22
Lineage    Species: Lactobacillus acidophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus acidophilus
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Bacteriocin lacticin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03771   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lacticin Q inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Lactobacillus acidophilus [1]
                              Lantibiotic carnocin-UI49 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03803   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic carnocin-UI49 inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Lactobacillus acidophilus [2]
                              Neurokinin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04249   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Neurokinin A inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Lactobacillus acidophilus (MIC > 500 ug/ml) [3]
                              Nisin U Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04320   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Nisin U inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Lactobacillus acidophilus [4]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Lactobacillus acidophilus [5]
References
1 Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria. Appl Environ Microbiol. 2007 May;73(9):2871-7.
2 Purification and characterization of a new bacteriocin isolated from a Carnobacterium sp. Appl Environ Microbiol. 1992 May;58(5):1417-22.
3 Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites. J Neuroimmunol. 2008 Aug 30;200(1-2):11-6.
4 Molecular and genetic characterization of a novel nisin variant produced by Streptococcus uberis. Appl Environ Microbiol. 2006 Feb;72(2):1148-56.
5 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.

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