Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1719)
DME Name Alpha-galactosidase (melA), Streptococcus thermophilus DME Info
UniProt ID
A0A564RX90_STRTR
EC Number    EC: 3.2.1.22     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.22
Lineage    Species: Streptococcus thermophilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus thermophilus
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Thermophilin 13 chain ThmA Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05132   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thermophilin 13 chain ThmA inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Streptococcus thermophilus [1]
                              Thermophilin 13 chain ThmB Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05133   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thermophilin 13 chain ThmB inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Streptococcus thermophilus [1]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of Alpha-galactosidase (melA) from Streptococcus thermophilus [2]
References
1 Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor. J Biol Chem. 1997 May 30;272(22):14277-84.
2 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.

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