Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1779)
DME Name	Dipeptidylpeptidase IV (DPP4), Streptococcus suis	DME Info
UniProt ID	A0A4T2GYT7_STRSU
EC Number	EC: 3.4.14.5 (Click to Show/Hide the Complete EC Tree) Hydrolases Peptidase Di/tripeptidyl peptidase EC: 3.4.14.5
Lineage	Species: Streptococcus suis (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Streptococcaceae Genus: Streptococcus Species: Streptococcus suis
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Amino Acid(s), Peptide(s) or Protein(s)
Peptide		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Pig beta-defensin BD-1		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02436 XEOTIC Info		Gene Form	Protein
Classification	Peptide
DME Modulation	Pig beta-defensin BD-1 inhibits the drug-metabolizing activity of Dipeptidylpeptidase IV (DPP4) from Streptococcus suis				[1]
Natural Product(s), Extract(s) or Medicine(s)
Plant Extract		Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
Syringa oblata aqueous extract		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO02314 XEOTIC Info		Gene Form	Protein
Classification	Plant Extract
DME Modulation	Syringa oblata aqueous extract inhibits the drug-metabolizing activity of Dipeptidylpeptidase IV (DPP4) from Streptococcus suis				[2]

References
1	Cloning and characterization of the gene for a new epithelial beta-defensinGenomic structure, chromosomal localization, and evidence for its constitutive expression. J Biol Chem. 1999 Aug 20;274(34):24031-7.
2	Syringa oblata Lindl. Aqueous extract is a potential biofilm inhibitor in S.suis. Front Pharmacol. 2017 Jan 30;8:26.

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