Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1779)
DME Name Dipeptidylpeptidase IV (DPP4), Streptococcus suis DME Info
UniProt ID
A0A4T2GYT7_STRSU
EC Number    EC: 3.4.14.5     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Di/tripeptidyl peptidase
EC: 3.4.14.5
Lineage    Species: Streptococcus suis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus suis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pig beta-defensin BD-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02436   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pig beta-defensin BD-1 inhibits the drug-metabolizing activity of Dipeptidylpeptidase IV (DPP4) from Streptococcus suis [1]
      Natural Product(s), Extract(s) or Medicine(s)
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Syringa oblata aqueous extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02314   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Syringa oblata aqueous extract inhibits the drug-metabolizing activity of Dipeptidylpeptidase IV (DPP4) from Streptococcus suis [2]
References
1 Cloning and characterization of the gene for a new epithelial beta-defensinGenomic structure, chromosomal localization, and evidence for its constitutive expression. J Biol Chem. 1999 Aug 20;274(34):24031-7.
2 Syringa oblata Lindl. Aqueous extract is a potential biofilm inhibitor in S.suis. Front Pharmacol. 2017 Jan 30;8:26.

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