Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1872)
DME Name Unclear metabolic mechanism (DME-unclear), Fusarium solani DME Info
Lineage    Species: Fusarium solani     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Sordariomycetes
Order: Hypocreales
Family: Nectriaceae
Genus: Fusarium
Species: Fusarium solani
Subspecies: Fusarium solani F-0007
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      34 Xenobiotics
                              A. clavatus peptide AcAMP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02122   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation A. clavatus peptide AcAMP inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [1]
                              Antifungal protein Pr-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02255   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antifungal protein Pr-2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [2]
                              Antimicrobial peptide WAMP-1a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02264   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antimicrobial peptide WAMP-1a inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [3], [4]
                              ARD1 Mutant ETD135 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03332   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ARD1 Mutant ETD135 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [5]
                              ARD1 Mutant ETD151 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03335   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation ARD1 Mutant ETD151 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [5]
                              Colutellin-A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02906   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Colutellin-A inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [6]
                              Defensin So-D5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03107   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin So-D5 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [7]
                              Defensin So-D6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03108   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Defensin So-D6 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [7]
                              Hepcidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03542   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hepcidin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani (MIC = 24 microM) [8], [9]
                              Hevein C-terminal domain WjAMP-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05287   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hevein C-terminal domain WjAMP-1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [10]
                              Human drosomycin-like defensin DLD Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03597   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Human drosomycin-like defensin DLD inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani (MIC = 25 microM) [11]
                              KW5 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01784   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation KW5 peptide inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Lactoferricin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03776   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lactoferricin B inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [13]
                              Non-specific lipid transfer peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04327   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Non-specific lipid transfer peptide inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [14], [15]
                              Osmotin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04411   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Osmotin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [16]
                              P. sylvestris defensin PsDef1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04738   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation P. sylvestris defensin PsDef1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [17]
                              Peptide (KW)3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01782   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide (KW)3 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Peptide (KW)4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01783   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide (KW)4 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Peptide (RW)2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01788   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide (RW)2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Peptide (RW)5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01795   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Peptide (RW)5 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Pisum sativum defensin Psd2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04614   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pisum sativum defensin Psd2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani (MIC = 5.0 ug/ml) [18]
                              Plant defensin Hc-AFP1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03526   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plant defensin Hc-AFP1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [19]
                              Plant defensin Hc-AFP2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03527   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plant defensin Hc-AFP2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [19]
                              Plant defensin Hc-AFP3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03528   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plant defensin Hc-AFP3 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [19]
                              Plant defensin Hc-AFP4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03529   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plant defensin Hc-AFP4 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [19]
                              Pseudothionin solanum tuberosum 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04756   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pseudothionin solanum tuberosum 1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [20]
                              RW3 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01790   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation RW3 peptide inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              RW4 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01792   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation RW4 peptide inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [12]
                              Snakin-1 StSN1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04960   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Snakin-1 StSN1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [21], [22]
                              Snakin-2 StSN2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04961   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Snakin-2 StSN2 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [21]
                              Sugarcane defensin Sd1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04919   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sugarcane defensin Sd1 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [23]
                              Sugarcane defensin Sd5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04920   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sugarcane defensin Sd5 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [23]
                              Viscotoxin-A3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05246   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Viscotoxin-A3 inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [24]
                              Viscotoxin-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05247   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Viscotoxin-B inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Fusarium solani [25], [26]
References
1 A highly thermostable antimicrobial peptide from Aspergillus clavatus ES1: biochemical and molecular characterization. J Ind Microbiol Biotechnol. 2010 Aug;37(8):805-13.
2 Antifungal mechanism of a novel antifungal protein from pumpkin rinds against various fungal pathogens. J Agric Food Chem. 2009 Oct 14;57(19):9299-304.
3 A novel antifungal hevein-type peptide from Triticum kiharae seeds with a unique 10-cysteine motif. FEBS J. 2009 Aug;276(15):4266-75.
4 Diversity of wheat anti-microbial peptides. Peptides. 2005 Nov;26(11):2064-73.
5 Lead optimization of antifungal peptides with 3D NMR structures analysis. Protein Sci. 2004 Mar;13(3):703-13.
6 Colutellin A, an immunosuppressive peptide from Colletotrichum dematium. Microbiology. 2008 Jul;154(Pt 7):1973-1979.
7 Novel defensin subfamily from spinach (Spinacia oleracea). FEBS Lett. 1998 Sep 18;435(2-3):159-62.
8 Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide. Peptides. 2009 Apr;30(4):638-46.
9 Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 2009 Jun;26(6):864-70.
10 C-terminal domain of a hevein-like protein from Wasabia japonica has potent antimicrobial activity. Plant Cell Physiol. 2003 Mar;44(3):296-303.
11 Drosomycin-like defensin, a human homologue of Drosophila melanogaster drosomycin with antifungal activity. Antimicrob Agents Chemother. 2008 Apr;52(4):1407-12.
12 Antifungal activity of (KW)n or (RW)n peptide against Fusarium solani and Fusarium oxysporum. Int J Mol Sci. 2012 Nov 15;13(11):15042-53.
13 Effects of lactoferricin B against keratitis-associated fungal biofilms. J Infect Chemother. 2012 Oct;18(5):698-703.
14 A non-specific lipid transfer protein with antifungal and antibacterial activities from the mung bean. Peptides. 2004 Aug;25(8):1235-42.
15 Characterization and structural analyses of nonspecific lipid transfer protein 1 from mung bean. Biochemistry. 2005 Apr 19;44(15):5703-12.
16 Osmotin purified from the latex of Calotropis procera: biochemical characterization, biological activity and role in plant defense. Plant Physiol Biochem. 2011 Jul;49(7):738-43.
17 Purification and molecular cloning of antimicrobial peptides from Scots pine seedlings. Peptides. 2009 Dec;30(12):2136-43.
18 Characterization of two novel defense peptides from pea (Pisum sativum) seeds. Arch Biochem Biophys. 2000 Jun 15;378(2):278-86.
19 Four plant defensins from an indigenous South African Brassicaceae species display divergent activities against two test pathogens despite high sequence similarity in the encoding genes. BMC Res Notes. 2011 Oct 28;4:459.
20 Pseudothionin-St1, a potato peptide active against potato pathogens. Eur J Biochem. 1994 Jul 1;223(1):135-9.
21 Snakin-2, an antimicrobial peptide from potato whose gene is locally induced by wounding and responds to pathogen infection. Plant Physiol. 2002 Mar;128(3):951-61.
22 Snakin-1, a peptide from potato that is active against plant pathogens. Mol Plant Microbe Interact. 1999 Jan;12(1):16-23.
23 Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins. Plant Mol Biol. 2008 Nov;68(4-5):321-35.
24 NMR structural determination of viscotoxin A3 from Viscum album L. Biochem J. 2000 Sep 1;350 Pt 2:569-77.
25 Isolation and characterization of cDNAs encoding viscotoxins of mistletoe (Viscum album). Eur J Biochem. 1991 Jun 15;198(3):549-53.
26 Comparative membrane interaction study of viscotoxins A3, A2 and B from mistletoe (Viscum album) and connections with their structures. Biochem J. 2003 Aug 15;374(Pt 1):71-8.

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