Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1946)
DME Name Azoreductase (azoR), Shigella dysenteriae DME Info
UniProt ID
AZOR_SHIDS
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Shigella dysenteriae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella dysenteriae
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      18 Xenobiotics
                              Bacteriocin E50-52 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02376   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin E50-52 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae [1]
                              Bacteriocin L-1077 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02378   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin L-1077 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 0.76 ug/ml) [2]
                              Dybowskin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03235   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 50 ug/ml) [3]
                              Dybowskin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03237   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 15 ug/ml) [3]
                              Dybowskin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03238   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-4 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 30 ug/ml) [3]
                              Dybowskin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03239   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Dybowskin-5 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 50 ug/ml) [3]
                              Enterocin E-760 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03253   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin E-760 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 0.1 ug/ml) [4]
                              L5K5Wn model peptide L5K5W1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03746   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W1 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W10 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03747   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W10 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 1 ug/ml) [5]
                              L5K5Wn model peptide L5K5W11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03748   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W11 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03749   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W2 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 1 ug/ml) [5]
                              L5K5Wn model peptide L5K5W3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03750   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W3 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03751   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W4 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03752   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W5 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03754   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W7 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              L5K5Wn model peptide L5K5W8 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03755   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W8 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 4 ug/ml) [5]
                              L5K5Wn model peptide L5K5W9 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03756   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation L5K5Wn model peptide L5K5W9 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 2 ug/ml) [5]
                              Plant JCpep7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03671   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plant JCpep7 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Shigella dysenteriae (MIC = 48 ug/ml) [6]
References
1 Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. J Agric Food Chem. 2008 Mar 26;56(6):1942-8.
2 Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum. Appl Environ Microbiol. 2011 Apr;77(8):2749-54.
3 Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. Peptides. 2007 Aug;28(8):1532-9.
4 Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2008 Mar;52(3):1094-100.
5 Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities. Molecules. 2013 Jan 11;18(1):859-76.
6 Efficient screening of a novel antimicrobial peptide from Jatropha curcas by cell membrane affinity chromatography. J Agric Food Chem. 2011 Feb 23;59(4):1145-51.

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