Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1957)
DME Name Methylenetetrahydrofolate reductase (metF), Streptococcus sanguinis DME Info
UniProt ID
A3CL12_STRSV
EC Number    EC: 1.5.1.20     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.20
Lineage    Species: Streptococcus sanguinis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus sanguinis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              C16-33 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02670   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation C16-33 peptide inhibits the drug-metabolizing activity of Methylenetetrahydrofolate reductase (metF) from Streptococcus sanguinis [1]
                              G2 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03433   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation G2 peptide inhibits the drug-metabolizing activity of Methylenetetrahydrofolate reductase (metF) from Streptococcus sanguinis [1]
                              M8-33 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03978   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation M8-33 peptide inhibits the drug-metabolizing activity of Methylenetetrahydrofolate reductase (metF) from Streptococcus sanguinis [1]
                              Mutacin-1140 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04155   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin-1140 inhibits the drug-metabolizing activity of Methylenetetrahydrofolate reductase (metF) from Streptococcus sanguinis [2]
References
1 Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide. Antimicrob Agents Chemother. 2006 Nov;50(11):3651-7.
2 Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics. Eur J Biochem. 2000 Dec;267(23):6810-6.

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