Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2014)
DME Name Insulin-degrading enzyme (ide), Vibrio vulnificus DME Info
UniProt ID
A0A0C1JXV9_9BACT
EC Number    EC: 3.4.24.56     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Metallopeptidase
EC: 3.4.24.56
Lineage    Species: Vibrio vulnificus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Vibrionales
Family: Vibrionaceae
Genus: Vibrio
Species: Vibrio vulnificus
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        7 Xenobiotics
                              Penaeidin-2d Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04506   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-2d inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC > 20 microM) [1], [2]
                              Penaeidin-3a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04507   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC > 20 microM) [3]
                              Penaeidin-3a T8A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01827   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-3a T8A inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC > 50 microM) [3]
                              Penaeidin-4a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04510   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penaeidin-4a inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC > 50 microM) [1], [4]
                              TFPI-1 C-terminal peptide TO17 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05154   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation TFPI-1 C-terminal peptide TO17 inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC = 80 microM) [5]
                              TO17 peptide derivative CTO17 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02967   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation TO17 peptide derivative CTO17 inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC = 20 microM) [5]
                              TO17 peptide derivative TO19 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05155   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation TO17 peptide derivative TO19 inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus (MIC = 20 microM) [5]
      Health or Environmental Toxicant(s)
                  Health Hazard/Toxicant Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Pyrogallol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01446   XEOTIC Info Gene Form Protein
                                 Classification Health Hazard
                                 DME Modulation Pyrogallol inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [6]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Actinomycetes A66 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02983   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Actinomycetes A66 culture supernatant inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [7]
                              Actinomycetes A67 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02984   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Actinomycetes A67 culture supernatant inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [7]
                              Actinomycetes B15 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02985   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Actinomycetes B15 culture supernatant inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [7]
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Anthranilate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02235   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Anthranilate inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [8]
                              Cinnamic aldehyde Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01253   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Cinnamic aldehyde inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [9]
      Pharmaceutical Agent(s)
                  Drug in Phase 3 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Curcumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00683   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 3
                                 DME Modulation Curcumin inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [10]
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              L-tryptophan Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03968   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation L-tryptophan inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [8]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              2-(2-Thienylsulfonyl)ethanethioamide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01894   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 2-(2-Thienylsulfonyl)ethanethioamide inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [6]
                              Methyl 4-boronobenzoate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02043   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Methyl 4-boronobenzoate inhibits the drug-metabolizing activity of Insulin-degrading enzyme (ide) from Vibrio vulnificus [6]
References
1 Diversity of the penaeidin antimicrobial peptides in two shrimp species. Immunogenetics. 2002 Sep;54(6):442-5.
2 Recombinant expression and range of activity of penaeidins, antimicrobial peptides from penaeid shrimp. Eur J Biochem. 1999 Dec;266(2):335-46.
3 Solution structure of the recombinant penaeidin-3, a shrimp antimicrobial peptide. J Biol Chem. 2003 Sep 19;278(38):36859-67.
4 A new class (penaeidin class 4) of antimicrobial peptides from the Atlantic white shrimp (Litopenaeus setiferus) exhibits target specificity and an independent proline-rich-domain function. Biochem J. 2004 Jul 1;381(Pt 1):79-86.
5 TO17: a teleost antimicrobial peptide that induces degradation of bacterial nucleic acids and inhibits bacterial infection in red drum, Sciaenops ocellatus. Fish Shellfish Immunol. 2018 Jan;72:639-645.
6 AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ. Microbiology. 2009 Dec;155(Pt 12):4114-4122.
7 Inhibition of Vibrio biofilm formation by a marine actinomycete strain A66. Appl Microbiol Biotechnol. 2007 Oct;76(5):1137-44.
8 Anti-biofilm effects of anthranilate on a broad range of bacteria. Sci Rep. 2017 Aug 17;7(1):8604.
9 Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio sppby decreasing the DNA-binding activity of the quorum sensing response regulator LuxR. BMC Microbiol. 2008 Sep 16;8:149.
10 Prevention of quorum-sensing-mediated biofilm development and virulence factors production in Vibrio sppby curcumin. Appl Microbiol Biotechnol. 2013 Dec;97(23):10177-87.

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