Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2021)
DME Name Carbapenemase (cphA), Achromobacter xylosoxidans DME Info
UniProt ID
A0A3G1JAD7_ALCXX
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Achromobacter xylosoxidans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Achromobacter
Species: Achromobacter xylosoxidans
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Penicillic acid Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04518   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Penicillic acid inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Achromobacter xylosoxidans [1]
      Pharmaceutical Agent(s)
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Patulin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04478   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Patulin inhibits the drug-metabolizing activity of Carbapenemase (cphA) from Achromobacter xylosoxidans [2]
References
1 Cancer genesTelling changes of base. Nature. 1991 Apr 4;350(6317):377-8.
2 Isolate-specific effects of patulin, penicillic Acid and EDTA on biofilm formation and growth of dental unit water line biofilm isolates. Curr Microbiol. 2010 Aug;61(2):148-56.

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