Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2059)
DME Name Beta-galactosidase (bgaB), Cronobacter sakazakii DME Info
UniProt ID
BGAL_CROS8
EC Number    EC: 3.2.1.23     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.23
Lineage    Species: Cronobacter sakazakii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Cronobacter
Species: Cronobacter sakazakii
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Natural Product(s), Extract(s) or Medicine(s)
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        9 Xenobiotics
                              Allium sativum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04088   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Allium sativum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Cinnamomum verum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04091   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Cinnamomum verum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Coriandrum sativum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04092   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Coriandrum sativum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Cuminum cyminum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04093   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Cuminum cyminum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Fenugreek methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04101   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Fenugreek methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Myristica fragrans methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04095   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Myristica fragrans methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Piper nigrum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04097   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Piper nigrum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Syzygium aromaticum methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04100   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Syzygium aromaticum methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
                              Zingiber officinale methanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04103   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Zingiber officinale methanolic extract inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [1]
      Pharmaceutical Agent(s)
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Citral Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01254   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Citral inhibits the drug-metabolizing activity of Beta-galactosidase (bgaB) from Cronobacter sakazakii [2]
References
1 Inhibition of quorum-sensing-mediated biofilm formation in Cronobacter sakazakii strains. Microbiology. 2016 Sep;162(9):1708-1714.
2 Inhibition of Cronobacter sakazakii virulence factors by citral. Sci Rep. 2017 Feb 24;7:43243.

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