Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME2071)
DME Name Beta-lactamase (blaB), Bacillus pumilus DME Info
UniProt ID
A0A498U5Y1_BACPU
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Bacillus pumilus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Bacillaceae
Genus: Bacillus
Species: Bacillus pumilus
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      13 Xenobiotics
                              CP-P derivative K11 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03678   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CP-P derivative K11 inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 0.5 ug/ml) [1]
                              Esculentin-2-Ala Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03300   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Esculentin-2-Ala inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 2.5 ug/ml) [2]
                              Esculentin-2-ALb Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03301   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Esculentin-2-ALb inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 2.5 ug/ml) [2]
                              Insect PP102 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04711   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect PP102 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 23.3 microM) [3]
                              Insect PP113 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04712   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect PP113 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 23.3 microM) [3]
                              Insect PP13 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04713   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Insect PP13 peptide inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 9 microM) [3]
                              Temporin-ALd Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05077   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALd inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 2.5 ug/ml) [2]
                              Temporin-ALe Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05078   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALe inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 5 ug/ml) [2]
                              Temporin-ALf Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05079   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALf inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 5 ug/ml) [2]
                              Temporin-ALg Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05080   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALg inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 2.5 ug/ml) [2]
                              Temporin-ALh Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05081   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALh inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 7.5 ug/ml) [2]
                              Temporin-ALi Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05082   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALi inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 7.5 ug/ml) [2]
                              Temporin-ALj Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05083   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-ALj inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus (MIC = 15 ug/ml) [2]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bacillus licheniformis SP1 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02990   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus licheniformis SP1 culture supernatant inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus [4]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Acacia arabica stem extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04987   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Acacia arabica stem extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus [5]
                              Tamarix aphylla bark extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02412   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Tamarix aphylla bark extract inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Bacillus pumilus [5]
References
1 The Design and Construction of K11: A Novel alpha-Helical Antimicrobial Peptide. Int J Microbiol. 2012;2012:764834.
2 Five novel antimicrobial peptides from skin secretions of the frog, Amolops loloensis. Comp Biochem Physiol B Biochem Mol Biol. 2010 Jan;155(1):72-6.
3 Novel antimicrobial peptides identified from an endoparasitic wasp cDNA library. J Pept Sci. 2010 Jan;16(1):58-64.
4 Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of Bacillus licheniformis. Microb Cell Fact. 2011 Sep 27;10:74.
5 Identification of oral cavity biofilm forming bacteria and determination of their growth inhibition by Acacia arabica, Tamarix aphylla Land Melia azedarach Lmedicinal plants. Arch Oral Biol. 2017 Sep;81:175-185.

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