Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0399)
DME Name Farnesol dehydrogenase (AKR1B15), Homo sapiens
Synonyms Aldo-keto reductase family 1 member B15; Testosterone 17beta-dehydrogenase; Estradiol 17-beta-dehydrogenase AKR1B15; AKR1B15
Gene Name AKR1B15
UniProt ID
AK1BF_HUMAN
Gene ID
441282
EC Number    EC: 1.1.1.54     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.54
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
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       Interactions between Microbiome and DME (MICBIO)                       
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQ
EKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGD
DFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFD
FKEFSHLEDFPFDAEY
Pathway Estrogen biosynthesis (R-HSA-193144 )
Function This enzyme catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, it catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta- hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It displays strong enzymatic activity toward all-trans- retinal and 9-cis-retinal and may play a physiological role in retinoid metabolism.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Estrone
 Drug Info Approved Menopausal disorder ICD11: GA30 [1]
Testosterone cypionate
 Drug Info Approved Testosterone deficiency ICD11: 5A81 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
E-3A
 Drug Info Phase 3 Turner syndrome ICD11: LD50 [1]
BRN-2217626
 Drug Info Phase 3 Female infertility ICD11: GA31 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrobenzaldehyde
 Drug Info Investigative Discovery agent ICD: N.A. [2]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          4 Drugs
Estrone
 Drug Info Approved Menopausal disorder Km = 0.0035 microM [1]
Testosterone cypionate
 Drug Info Approved Testosterone deficiency Km = 0.0071 microM [1]
E-3A
 Drug Info Phase 3 Turner syndrome Km = 0.0091 microM [1]
BRN-2217626
 Drug Info Phase 3 Female infertility Km = 0.0028 microM [1]
References
1 Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem. 2015 Mar 6;290(10):6531-45.
2 Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30;191(1-3):177-84.

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