Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME0472)
DME Name Retinol dehydrogenase 14 (RDH14), Homo sapiens
Synonyms Dehydrogenase/reductase family 7C member 4; Alcohol dehydrogenase PAN2; Short chain dehydrogenase/reductase family 7C member 4; PAN2; RDH14; SDR7C4; UNQ529/PRO1072
Gene Name RDH14
UniProt ID
RDH14_HUMAN
Gene ID
57665
EC Number    EC: 1.1.1.300     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.300
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA
AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR
SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK
SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV
TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG
RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
Pathway RA biosynthesis pathway (R-HSA-5365859 )
Function This enzyme has a clear preference for NADP. It displays high activity towards 9-cis, 11-cis and all-trans-retinol, a very weak activity towards 13-cis-retinol but no activity towards steroid.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Dihydrocozymase
 Drug Info Investigative Discovery agent ICD: N.A. [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          1 Drugs
Dihydrocozymase
 Drug Info Investigative Discovery agent Km = 1200 microM [1]
References
1 Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. FEBS Lett. 2002 Nov 20;531(3):489-93.

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