Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1013)
DME Name Beta-lactamase (blaB), Pseudoflavonifractor capillosus
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; BACCAP_02761
Gene Name blaB
UniProt ID
A6NX15_9FIRM
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Pseudoflavonifractor capillosus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Pseudoflavonifractor
Species: Pseudoflavonifractor capillosus
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MYTHSAGGKFLILFSFDSTAGRWDNFFEAQGKSRERMNAAMWKKRLSALALTAVMAVSIS
APALAAETEAPATRDESAAMAAQYAAQYGGAVSVQYAVWQDGEITVSGHAGVYSKSENRV
LLDTDLYGIGSVSKMYVTAAVMQLVEQGKINLDAPVTKYLPEFKMADERYKDITVRMLLN
HSSGLMSATHNMLLFADDDRSATENLLETLSTQRLAADPGAYSTYCNTGFTLAELVVEAV
SGKTFPEYLHEAILAPNSLENTFTPQDEFDTSRLVKTYLGEDPRALPQDCLGTVGTGGIY
ANAADLAAFGGLLCSDELLTSASLDAMAAPEYSNGIWPDDADDSLAFGLGWDTVSLAPFG
YNDIQALAKGGDTQYYHAALVVLPEYDMAAAVLTSGGVSTYNQMAASRMLIDALAEQGVA
VDETVPTLPAATPSQTMPAELMDYSGYYASTLQQFKVDISADGVLTLQSLTVPSAPAQTF
YYFDDGSFRDQTGTAAMVKPVVEKNGQTYLWQKAYAFLLGLTVLPTSNYVGQKVEPAQLT
EDVQAAWDKWNTTSVLPLNEKYSSQVWLSLGSAAVTELPEYIPGYVGAQKIVDANHTQFA
VQVPGNAGRDGSDVTVWEEDGHVWMSAQGLLYADASIAQPIYCGAGAYSTVQPDGYARWY
TVGSAAGLTIQVEIEGNGGFYVYDGTGSLAASSVVWGDSTVTLPENGVIAFAGDAGARFH
ISVVSAE
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
References
1 The prevalence of beta-lactamase producing bacteria in subgingival plaque and their sensitivity to Augmentin. Br J Oral Maxillofac Surg. 1990 Jun;28(3):180-4.

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