Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1020)
DME Name Beta-lactamase (blaB), Acidaminococcus fermentans
Synonyms Penicillinase; Cephalosporinase; Beta-lactam; aci1
Gene Name aci1
UniProt ID
Q9XBM2_ACIFE
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Acidaminococcus fermentans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Negativicutes
Order: Acidaminococcales
Family: Acidaminococcaceae
Genus: Acidaminococcus
Species: Acidaminococcus fermentans
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MKKFCFLFLIICGLMVFCLQDCQARQKLNLADLENKYNAVIGVYAVDMENGKKICYKPDT
RFSYCSTHKVFTAAELLRQKNTSDLNEIRKFSAEDILSYAPITKDHVADGMTLAEICSAS
LRWSDNTAANLILQEIGGVENFKVALKNIGDKTTKPARNEPELNLFNPKDNRDTSTPRQM
VKNLQVYIFGDILSDDKKKLLIDWMSDNSITDTLIKAETPQGWKVIDKSGSGDYGARNDI
AVIYPPNRKPIVMAIMSRRTEKNAKSDDAMIAEAAKRIFDNLVF
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Amoxicillin
 Drug Info Approved Acute otitis media ICD11: AB00 [1]
Cefotaxime
 Drug Info Approved Meningitis ICD11: 1A62 [1]
References
1 ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci. Antimicrob Agents Chemother. 2000 Nov;44(11):3144-9.

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