General Information of DME (ID: DME1039)
DME Name Molybdopterin-dependent enzyme (molD), Klebsiella pneumoniae
Synonyms Molybdopterin-dependent oxidoreductase; Oxidoreductase molD; molD
Gene Name molD
UniProt ID
A0A327SQQ7_9ACTN
EC Number    EC: 1.1.1.40     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.40
Lineage    Species: Klebsiella pneumoniae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MATFTPGFHGHRRTRGGRLPPGQFLTEDFPVLSAGPTPDIPLDRWEFTLTAESGERRRWN
WQEFSALPQQEVTTDLHCVTRWSKFDTRWRGVSLDTLLNGVTTDARHALAECHGGYTTNL
PLTDLRGGKAWIAHTYDGEPLTAEHGGPARLLVPHLYFWKSAKWISGITLRAEDHRGFWE
QLGYHDHGDPWREQRTWND
Function This enzyme catalyzes the conversion of doxorubicin to 7-deoxydoxorubicinol and 7-deoxydoxorubicinolone via a reductive deglycosylation mechanism.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Doxorubicin
Drug Info Approved Breast cancer ICD11: 2C60 [1]
References
1 Transformation of the anticancer drug doxorubicin in the human gut microbiome. ACS Infect Dis. 2018 Jan 12;4(1):68-76.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.