Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1041)
DME Name NADH dehydrogenase (nuoE), Streptomyces griseus
Synonyms DPNH-menadione reductase; FMN-dependent NADH-quinone reductase; D-diaphorase; Reduced nicotinamide adenine dinucleotide (quinone); FMN-dependent NADH:quinone oxidoreductase; H+(NA+)-translocating NADH-quinone oxidoreductase; NADH-dependent 1,4-benzoquinone reductase; NADH-Q oxidoreductase; NADH dehydrogenase subunit E; nuoE
Gene Name nuoE
UniProt ID
J9VB37_9ACTN
EC Number    EC: 1.6.5.11     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
NADH/NADPH oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.6.5.11
Lineage    Species: Streptomyces griseus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces griseus
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTDGQTSLGMPQLPAPDYPAEVRARLEADAEEIIARYPGSRSALLPLLHLVQSEEGHVTR
TGMKFCAEILGLTTAEVTAVATFYTMYRRKPSGDYQVGVCTNTLCAVMGGDAIFEELKEH
LGVGNNETTEDGKVTLEHIECNAACDFAPVVMVNWEFFDNQTPDSAKKIVDDLRAGRPVE
PTRGAPLCTYKETARILAGFPDEREGAVEATGGAGPASLVGLRLAKGETPHHKIVHPRGE
SASGEGE
Function This enzyme is inhibited by AMP and 2,4-dinitrophenol but not by dicoumarol or folic acid derivatives.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Doxorubicin
 Drug Info Approved Breast cancer ICD11: 2C60 [1]
References
1 Bacterial inactivation of the anticancer drug doxorubicin. Chem Biol. 2012 Oct 26;19(10):1255-64.

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