| General Information of DME (ID: DME1056) |
| DME Name |
Cytidine deaminase (cdd), Klebsiella pneumoniae
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| Synonyms |
Cytidine aminohydrolase; Activation-induced cytidine deaminase; Canine hepatic cyd deaminase; AICDA; KPN78578_25410; KPN_02584
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| Gene Name |
cdd
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| UniProt ID |
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| EC Number |
EC: 3.5.4.5 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amidine hydrolase
EC: 3.5.4.5
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| Lineage |
Species: Klebsiella pneumoniae (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Klebsiella
Species: Klebsiella pneumoniae
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MHSRFQAALTTLAADLQAAIAPMLADPHFPALLEADQVATLQHATGLDEDALAFALLPLA
AACARPDLSHFNVGAIARGVSGRWYFGGNMEFLGATMQQTVHAEQSAISHAWLRGETSLR
AITVNYTPCGHCRQFMNELNSGLALRIHLPGREAHALEHYLPDAFGPKDLEIKTLLMDEQ
DHGFPVSGDALTQAAIQAANRCHAPYSHSPSGVALELKDGTIFSGSYAENAAFNPTLPPL
QGALNLLSLNGYDYPAIQRAILAEKADAALIQWDATVATLKALGCHNIERVLLG
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| Structure |
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| Pathway |
Metabolic pathways (kpn01100 ) |
| Pyrimidine metabolism (kpn00240 ) |
| Function |
This enzyme catalyzes the deamination of cytidine and 2'-deoxycytidine with similar efficiencies. It is involved in salvage of both exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
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