Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1064)
DME Name Nitroreductase (NTR), Giardia intestinalis
Synonyms FMN reductase (NAD(P)H); FMN reductase NADPH; nfrA2; DHA2_15307
Gene Name NTR
UniProt ID
A0A482G3K9_GIAIN
EC Number    EC: 1.5.1.39     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.39
Lineage    Species: Giardia intestinalis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metamonada
Phylum: Fornicata
Class: Diplomonadida
Order: Diplomonadida
Family: Hexamitidae
Genus: Giardia
Species: Giardia intestinalis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human vagina.
Sequence
MPPICDAILRRRAIKQYTKESVSIEAIEYLRKVAVAIPTGHNTRHTEFAFVTNPRIIKTI
SQAKGEKAEYMQHAKLLIVVMGIQNDGVTSIATDMSIAAAMIQLACSDFGLACSWEQFYG
RKNVYGEDSERIVLDVLRLLNSPNRRVLCALAIGYPAVQMPPADMHENGRIYMIE
Function This enzyme uses NADH as source of reducing equivalents to reduce of a variety of nitroaromatic compounds.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Metronidazole
 Drug Info Approved Amebiasis ICD11: 1A36 [1]
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Fexinidazole
 Drug Info Phase 2/3 Trypanosomiasis ICD11: 1D51-1F53 [2]
References
1 Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb;53(2):458-64.
2 Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation

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