Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1081)
DME Name Azoreductase (azoR), Enterococcus casseliflavus
Synonyms Azo-dye reductase; FMN-dependent NADH-azo compound oxidoreductase; FMN-dependent NADH-azoreductase; azoR; HSIEG1_1039
Gene Name azoR
UniProt ID
T0VG26_9ENTE
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Enterococcus casseliflavus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus casseliflavus
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKNVLVVKANNRPDGVSAKMFDTFVENLDRTAVDVVTFDVYAQPMPYIGQTLFEAFGKLA
QEQDLNQEEQELMTVRQDVMNKFAAADTIVFAFPMWNLTIPAALHTFIDYIFQAGFTFSY
NEDGSMNQLLKDKEVVLLNARGGVYSGEMSGMESAVTFMEKVFGGMFGMTISDEVIIEGH
NADPSKTEEIIAAGLEKVAEAAKKF
Function This enzyme catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. And it requires NADH, but not NADPH, as an electron donor for its activity.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Sulfasalazine
 Drug Info Approved Rheumatoid arthritis ICD11: FA20 [1]
References
1 The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther. 1972 Jun;181(3):555-62.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.