Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1103)
DME Name Arylamine N-acetyltransferase (NAT), Citrobacter freundii
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; BEH70_05090; E6R41_12465; EVY18_22690
Gene Name nhoA
UniProt ID
A0A0D7LKP9_CITFR
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Citrobacter freundii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Citrobacter
Species: Citrobacter freundii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTPFLTAYFARIGWSDSASVDIETLKALHLLHNGAIPFENLDVLLPREMQLDDLSLEEKL
VTARRGGYCFEQNGVFERALREIGFNVRSLLGRVVLANPSSLPPRTHRLLLVELQGEQWI
ADVGFGGQTLTAPIRLQADIEQQTPHGEYRLVQEGDDWILQFRHHDHWQSMYRFDLVVQH
QSDYLMGNFWSAHWPQSHFRHHLLMCRHLPDGGKLTLTNFHFTRYQDGRAVEQINLPDVA
SLYALLQEQFGLGVDDVKHGFTEDELATVMAAFDTHPEAGK
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Asacolitin
 Drug Info Investigative Inflammatory bowel disease ICD11: DD72 [1]
References
1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.

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