Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1118)
DME Name Glutamate decarboxylase (gadB), Lactobacillus johnsonii
Synonyms Glutamic acid decarboxylase; Bacterial glutamate--ammonia ligase; gad; gadB; GAD-beta
Gene Name gadB
UniProt ID
A9ZM78_LACBR
EC Number    EC: 4.1.1.15     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.15
Lineage    Species: Lactobacillus johnsonii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus johnsonii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MMNKNDQETQQMINNVDLEKTFLGSVEAGQSLPTYTLPDDPMAPDVAAQLVEHYRLNEAK
ANQNLATFCTTQMEPQADELMKNALNTNAIDKSEYPKTAAMENYCVSMIAHLWGIPDNEK
IYDDFIGTSTVGSSEGCMLGGLALLHSWKHRAKAAGFDIEDLHSHKPNLVIMSGYQVVWE
KFCTYWNVEMRQVPINGDQVSLDMDHVMDYVDENTIGIIGIEGITYTGSVDDIQTLDNLV
TEYNKTATMPVRIHVDAAFGGLFAPFVDGFNPWDFRLKNVVSINVSGHKYGMVYPGLGWI
VWRHDTADILPAEMRFQVPYLGKTVDSIAINFSHSGAHISAQYYNFIRFGLSGYKTIMQN
VRKVSLKLTAALKTYGIFDILVDGSQLPINCWKLADDAPVGWTLYDLESELAKYGWQVPA
YPLPKNRDDVTISRIVVRPSMTMTIADDFLDDLKLAIDGLNHTFGVTTTVDQDNKTTVRS
Function This enzyme acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
L-glutamine
 Drug Info Approved Sickle-cell anaemia ICD11: 3A51 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
E-920
 Drug Info Phase 1 Lung cancer ICD11: 2C25 [2]
References
1 Exploring the contributions of two glutamate decarboxylase isozymes in Lactobacillus brevis to acid resistance and gamma-aminobutyric acid production. Microb Cell Fact. 2018 Nov 19;17(1):180.
2 The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase

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